The South African Population Research Infrastructure Network (SAPRIN) is a partnership between public, and academic institutions, aiming to produce high-quality research. It is part of the Department of Science, Technology and Innovation's (DSTI) strategy to enhance research capacity in the country and aligns with the DSTI's South African Research Infrastructure Roadmap (SARIR). SAPRIN is hosted by the South African Medical Research Council (SAMRC) and operates through three Health and Demographic Surveillance Sites (HDSS) located in Bushbuckridge (Agincourt), Polokwane (DIMAMO), and Mtubatuba (AHRI). Recently, four additional HDSSs have been established in Gauteng (GRT-INSPIRED in Hillbrow, Atteridgeville, and Melusi), the Western Cape (C-SHARP in Bishop Lavis and Nomzamo), KwaZulu-Natal (USINGA in Umlazi, eThekwini) and North West province (BAMMISHO in the Bojanala district). Each HDSS node aims to have a minimum population of 100,000 people, with a total of over 700,000 individuals and 140,000 geolocated households across the seven nodes.